Regeneron Jobs – Scientist, Protein Biochemistry

Job Description:

The Protein Biochemistry Group at Regeneron is seeking a biophysical chemist Scientist to provide analytical protein characterization through the use of ground-breaking technologies. You will be responsible for providing in-depth biophysical and biochemical characterization of proteins to support development programs in our pipeline. You will be expected to take on a role in applying a diverse array of sophisticated biophysical techniques to deepen our knowledge of labeled proteins and their heterogeneity to support regulatory submission. This is a permanent position in the Protein Biochemistry Group that will be responsible for development, purification and characterization of the critical protein reagents.

Job Responsibilities:

• Manage and mentor research associates and work as part of a collaborative team to meet project milestones
• Develop site-specific labeling methods as an orthogonal to amine coupling
• This position will provide the opportunity to make visible contributions to a variety of projects while interacting with a knowledgeable and dedicated multidisciplinary team
• Maintain documentation of experimental procedures and results in a laboratory notebook per established guidelines
• Provide timely support to internal and external collaborators and present results and reports at various meetings
• Manage stability testing program for critical protein reagents
• Provide well characterized protein reagents to other departments in the company and to collaborators
• Develop and implement new analytical techniques to assess the stability of labeled protein reagents including freeze/thaw studies; optimize labeling conditions and formulation buffers to improve reagent stability
• Conduct experiments to determine quality attributes of labeled drugs that impact downstream assays
• Purify and characterize labeled and unlabeled proteins and anti-drug antibodies at both small and large scale

Job Requirements:

• This role requires a PhD in Biochemistry, Bioengineering or related discipline with 0-2 years of experience with an emphasis on protein purification and characterization. Demonstrated solid proficiency in various protein purification techniques including affinity, ion exchange, gel filtration, HIC; strong FPLC/liquid chromatography experience.
• Experience with protein characterization techniques such as SDS-PAGE, Western blot, ELISA, Kinetic and Binding studies using SPR/BLI technology, CE-SDS, IEF/cIEF, SEC.
• Experience with additional analytical techniques, such as LC-MS, SEC-MALS, DLS, and DSC is a plus.
• Experience in labeling proteins with biotin, ruthenium, alexa fluor and other dye labels preferred.
• Ability to critically analyze and troubleshoot scientific problems.
• A high level of scientific initiative and ability to multi-task, prioritize work and handle multiple projects at once.
• Ability to work independently but also within a collaborative team environment and have flexibility to work on changing priorities.
• Excellent verbal and written communication skills.
• You have strong initiative and aim to complete challenging tasks and learn new technologies.
• You are capable of multi-tasking, working both independently and within a team environment.

Job Details:

Company:  Regeneron

Vacancy Type:  Full Time

Job Location: Oakland, CA, US

Application Deadline: N/A

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